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	Provedor de dados OAK (2) Autor Hashimoto, Makoto (2) Hatanaka, Yasumaru (2) Kato, Yuhi (1) Nabeta, Kensuke (1) Sadakane, Yutaka (1) Palavra-chave DIAZIRINE (2) PROTEINS (2) ACID (1) CARBENE-GENERATING REAGENT (1) DERIVATIVES (1) DOMAIN (1) EFFICIENT (1) FLAVIN BINDING-SITES (1) HIGH SPECIFIC RADIOACTIVITY (1) IDENTIFICATION (1) IODINATION METHOD (1) PHOTOAFFINITY (1) PHOTOPHORE (1) PROBES (1) RECEPTOR (1) Mais... Ano 2006 (1) 2002 (1) País Japan (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Simple method for the introduction of iodo-label on (3-trifluoromethyl) phenyldiazirine for photoaffinity labeling OAK Hashimoto, Makoto; Kato, Yuhi; Hatanaka, Yasumaru. A simple and mild method was developed for the introduction of iodo-label on (3-trifluoromethyl) phenyidiazirine (TPD) aromatic ring in the presence of three membered diazirine ring. An iodination protocol, I-2-BTI in CH3CN, was found to be effective even though affinity ligands are pre-installed. Palavras-chave: HIGH SPECIFIC RADIOACTIVITY; CARBENE-GENERATING REAGENT; IODINATION METHOD; PROBES; DERIVATIVES; DIAZIRINE; EFFICIENT; ACID; PHOTOPHORE; PROTEINS. Ano: 2006 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/733 Synthesis of tag introducible (3-trifluoromethyl)phenyldiazirine based photoreactive phenylalanine OAK Hashimoto, Makoto; Hatanaka, Yasumaru; Sadakane, Yutaka; Nabeta, Kensuke. An efficient synthesis of tag introducible (3-trifluoromethyl)phenyldiazirine based phenylalanine derivatives is described. Alkylation of a chiral glycine equivalent with a spacer containing (3-trifluoromethyl)phenyldiazirinyl bromides enables us to create photoreactive L-phenylalanine derivatives. After introduction of biotin at the spacer, the biotinylated and photoreactive amino acid was applied for L-amino acid oxidase and incorporated into a substrate binding site. These compounds will be powerful tools not only for photoaffinity labeling to elucidate properties of bioactive peptides but also as trifunctional photophors to introduce a ligand skeleton. (C) 2002 Elsevier Science Ltd. All rights reserved. Palavras-chave: FLAVIN BINDING-SITES; PHOTOAFFINITY; DIAZIRINE; IDENTIFICATION; PROTEINS; RECEPTOR; DOMAIN. Ano: 2002 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/713 Registros recuperados: 2 Primeira ... 1 ... Última

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